PROJECT 1: Bone anabolism in development and aging
We are the first to define a role for G protein gated inwardly-rectifying K+ channel 3 (GIRK3) in the musculoskeletal system. Girk3-/- mice have high bone mass that is adult-onset. This is innovative and relevant because osteoporosis and other diseases of low bone mass typically occur in older adults. The goal of this project is to characterize the cellular and molecular mechanisms by which GIRK3 deletion increases bone mass in the adult skeleton.
PROJECT 2: Bone regeneration post-lactation
Mammals mobilize a significant amount of their bone mass during lactation (up to 10% in humans) to support calcium demands of the growing neonate. Following the cessation of lactation, bone undergoes a remarkable building phase in which all (or nearly all) of the bone is recovered. The goal of this project is to define the factors dictating bone regeneration post-lactation.
PROJECT 3: Novel regulators of cartilage maintenance
Osteoarthritis is characterized by progressive degeneration of the cartilage within joints. Osteoarthritis is common and can cause severe morbidity and pain. Despite its wide prevalence, there are no disease-modifying therapies that can stop osteoarthritis progression or stimulate cartilage regeneration. The goal of this project is to define novel molecular drivers of cartilage maintenance and regeneration.
